Research Themes

Major research themes in clinical science at HCKR include:

Diagnosis and Management of Newly Diagnosed Kidney Disease

We are currently conducting a number of studies that will optimize the care of patients with newly diagnosed kidney disease. These studies include:

  • Evaluating the optimal timing for referral of a patient with newly diagnosed chronic kidney disease (CKD) to a nephrologist (SIM-CKD)
  • Optimizing fluid management in patients with acute kidney injury in the ICU (BIOVISION)
  • Evaluating treatment strategies in patients with renal vasculitis (PEXIVAS; FIG)

Progressive Chronic Kidney Disease

Chronic Kidney Disease (CKD) Research
Some patients with earlier stages of kidney disease will progress to more advanced chronic kidney disease and may ultimately need to start dialysis or receive a kidney transplant. Studies on these patients include:

  • The influence of fluid retention on outcomes in patients with CKD (CANPREDICT BIA)
  • Improving the use of home-based dialysis therapies (WISHED)

Patient-oriented Dialysis Research

About 25,000 patients in Canada require dialysis due to the failure of their kidney function. These patients often have poor quality of life and a shortened life expectancy. Studies are currently being conducted to improve their quality of life and reduce the risk of serious adverse clinical events. These studies include:

  • The use of a cardio-protective medication in hemodialysis patients (PHASE)
  • The impact of calcium-based phosphate binders on cardiovascular outcomes in HD patients (TARGET)
  • The impact of the hemodialysis treatment on patient’s symptoms (SYMPTOMS, HOST TIME, MORE Time, FLUID)
  • The optimal exercise regimen in hemodialysis patients to improve physical function and well-being (THESIS)
  • The optimal management of anticoagulation during hemodialysis (HEMOTIN)

Patient-oriented Transplant Research

Kidney transplantation improves the quality of life and life expectancy of patients who are dialysis-dependent. Nevertheless, patients with kidney transplantation are at increased risk of early cardiovascular disease and loss of the transplant kidney over time. A number of studies are underway evaluating predictors of cardiovascular disease in these patients and early predictors of graft loss:

  • Predictors of cardiovascular events in renal transplant patients (SCORE)
  • Identifying markers of early renal scarring in transplant recipients (FIG)
  • The risk of venous thromboembolism in patients with a newly received kidney transplant (REPORT)