Dr. Jeffrey Dickhout

Dr. Jeffrey Dickhout

Dr. Jeffrey Dickhout

Dr. Dickhout conducts research in the department of medicine, division of nephrology with laboratories located at St. Joseph’s HealthCare Hamilton in the Hamilton Centre for Kidney Research. He also is an educator in the Faculty of Health Sciences Medical Sciences Graduate Program and the McMaster University Medical School. His areas of research include:

  • Role of proteinuria in the progression of chronic kidney disease
  • Mechanisms by which hypertension induces chronic kidney disease
  • Endoplasmic Reticulum Stress in kidney disease and renal fibrosis

Dr. Dickhout received his Ph.D. in Medical Sciences from McMaster University. He trained as a Postdoctoral Fellow with Dr. Allen W. Cowley Jr. in the Department of Physiology at the Medical College of Wisconsin in renal physiology. Further Postdoctoral training was obtained in Dr. Richard C. Austin’s laboratory at McMaster University in cardiovascular disease. Dr. Dickhout was the inaugural holder of the Division of Nephrology Junior Researcher award. Dr. Dickhout is currently an Assistant Professor in the Department of Medicine, Division of Nephrology at McMaster University and St. Joseph’s Healthcare Hamilton. He has been awarded the Department of Medicine Internal Career Award and has recently been awarded the Krescent New Investigator Award from the Kidney Foundation of Canada.

Funding

Dr. Dickhout’s research program is currently supported by the CIHR and the Kidney Foundation of Canada where he holds funds as Principal Investigator into

  1. Endoplasmic reticulum (ER) stress in the development of kidney disease.
  2. Proteostasis in hypertension induced end organ damage.
  3. Endoplasmic reticulum (ER) stress and the unfolded protein response as modulators of inflammation in chronic disease.
  4. Inhibition of Acute Kidney Injury through CHOP/GADD153 suppression.

Dr. Dickhout also acknowledges support for his research program from St. Joseph’s Healthcare Hamilton and the Hamilton Centre for Kidney Research. Dr. Dickhout has also held funds as a Co-investigator with Dr. Richard C. Austin to determine small molecules that regulate the expression of the ER stress-inducible gene TDAG51.

Publications