Dr. Khalid Al-Nedawi

Dr. Khald Al-Nedawi

Dr. Khald Al-Nedawi


Dr. Al-Nedawi received his PhD in Medical Biology and Biotechnology from Medical University of Lodz, Poland. He received a post-doctoral fellowship supported by European Union hosted in Polish Academy of Science; he secured the position of scientific adjunct and head of transgenic animal facility at the center for medical research at the Polish Academy of Science. He joined McMaster University for one year as a post-doctoral fellow, then McGill University as a post-doctoral fellow and later as medical scientist and faculty lecturer in the Department of Pediatric Haematology & Oncology and the Montreal Children Hospital Research Institute. Dr. Al-Nedawi has received several awards and recognition for his scientific accomplishments. He is the winner of the 2010 Michael G. DeGroote academic fellowship award at McMaster University.

Research

Dr. Al-Nedawi has contributed to research on thrombosis haemostasis, cancer progression, angiogenesis, metastasis and biomarkers. Dr. Al-Nedawi’s main interest is the mechanisms of intercellular interactions through short peptides and exosomes / microvesicles. Dr. Al-Nedawi reported the mechanism by which cancer cells can shed oncogenic proteins via microvesicles to the neighboring non-cancer cells providing them with an ectopic transformed phenotype. Furthermore he reported the transfer of oncogenic proteins from cancer cells to tumour endothelial cells leading to an autocrine secretion of VEGF and autophosphorylation of VEGFR2. Detection of oncogenic proteins in the cargo of microvesicles circulating in the cancer patient’s peripheral blood, Dr. Al-Nedawi and his colleagues have a patent on using microvesicle/exosomes to look for prognostic and predictive biomarkers for different types of cancers. In addition, Dr Al-Nedawi is inventor in other three patents two of them filed recently through the McMaster Industry Liaison office (MILO). Dr. Al-Nedawi has been published in high ranked medical journals like “Blood, ATVB, NCB, PNAS”, and contributed to many international scientific conferences.

Representative peer-reviewed papers

  • Kathleen Gabriel, Alistair Ingram, Richard Austin, Anil Kapoor, Damu Tang, Fadwa Majeed, Talha Qureshi, and Khalid Al-Nedawi. Regulation of the tumor suppressor PTEN through exosomes: A diagnostic potential for prostate cancer. In press.
  • Al-Nedawi K., Meehan B., Kerbel R., Anthony C.Allison, Rak J. 2009. Endothelial Expression of Autocrine VEGF upon the Uptake of Tumour-Derived Microvesicles Containing Oncogenic EGFR. Proc Natl Acad Sci U S A. 106(10):3794-9.
  • Al-Nedawi K., Meehan B., Micaleff J., Lahotak W.,Guha Ab., Rak J. 2008. Intercellular Transfer of the Oncogenic EGFRvIII via Tumour Cell Derived Microvesicles. Nature Cell Biology. 10(5): 619-624.
  • Al-Nedawi K., Szemraj J. and Cierniewski CS. 2005. Mast Cell-Derived Exosomes Activate Endothelial Cells to Secrete Plasminogen Activator Inhibitor Type 1. Arteriosclerosis Thrombosis and Vascular Biology. 25(8):1744-1749.
  • Al-Nedawi K., Czyz M., Bednarek M., Szemraj J., Swiatkowska M., Cierniewska-Cieslak A., Wyczolkowska J., Cierniewski CS. 2004. Thymosin β4 Induces the Synthesis of Plasminogen Activator Inhibitor-1 in Cultured Endothelial Cells and Increases Its Extracellular Expression. Blood. 103(4):1319-1324.

Publications

Via PubMed, http://www.ncbi.nlm.nih.gov/pubmed?term=Al-Nedawi%20K